The new Sonicator 4000 is the world's most advanced ultrasonic processor. A variety of new features including digital processing and touch screen control make this the most intuitive and easy to use system available. Output amplitude is controlled from 0-100% giving a greater degree of resolution and the ability to pinpoint the amplitude needed to effectively process your sample.
The Sonicator tracks frequency changes in the convertor / tip assembly caused by load and temperature changes and maintains electrical efficiency at all times. This results in more efficient operation and consistent, reproducible results. Self diagnostics and help screens make operation simple and
trouble-free.
Cat. No. HS-S4000

Includes:
- Generator
- Converter
- Converter Cable
- 1/2" replaceable tip horn
- Power Cable
- Wrench Set
- Owner's Manual
Features:
Fully Digital Design
Digital signal processing enables precise control of amplitude and output power. The result is consistent and reproducible sample processing.
Amplitude Control
Output amplitude is controlled from 1-100% giving a greater degree of resolution and the ability to pinpoint the amplitude needed to effectively process your sample.
Expandable Operating System
Software updates and new features can be downloaded to the Sonicator through the USB port located on the back of the unit. Programs can be e-mailed to the end user and uploaded in minutes. This feature ensures the Sonicator 4000 will always be at the forefront ultrasonic processing.
Touch Screen Control
A large, color LCD touch screen clearly displays all operating parameters and options.
Self Diagnostics
In the event that a problem is detected, the sonicator will prompt the user that an error has occurred. Help screens offer step by step instructions to help solve the problem.
Programmability
Parameters including processing times, pulse on/off and amplitude can be saved to memory and run by the touch of a button.
Pulse Mode
Adjustable pulse On and Off times can be programmed from 1 second to 24 hours.
Run Multiple Programs in Sequence
Multiple programs can be run in sequence. For example, the unit can be programmed to sonicate at 50% amplitude for 5 minutes, shut off for 2 minutes and re-start at 25% amplitude for 10 minutes. Up to 6 programs can be run in succession.
Total Energy Output Display
Energy delivered to the probe is displayed in both Watts and Joules.
Auto Tuning
The Sonicator digitally tracks frequency changes in the convertor / tip assembly caused by load and temperature changes and maintains electrical efficiency at all times. Manual tuning (common on older systems) is not necessary.
Overload Protection
The unit is equipped with fault detection circuitry to shut down sonication in the event that an error is detected.
Temperature Monitoring
An optional temperature probe is available for those customers who wish to monitor the temperature of their sample. If the temperature limit is reached, sonication shuts down to prevent overheating of the sample.
RoHS Compliant
The new Sonicator is built lead free.
| Maximum Power Output |
600 Watts |
| Operating Frequency |
20 kHz |
| Input |
100 - 240V, 50 - 60Hz |
| Programmability |
10 memories plus sequencing |
| Programmable Timer |
1 second to 72 hours |
| Adjustable Pulse On/Off |
1 second to 24 hours |
| Dimensions |
11" wide x 20" long x 5.5" high |
Accessories for Sonicator 4000
Probe Options
Probes (also known as horns) are titanium tools, machined to specific sizes and shapes so when driven at their resonant frequency, they expand and contract longitudinally. This mechanical vibration is amplified and transmitted down the length of the probe. In liquid, the probe causes cavitation which has the ability to process samples.
Choosing the appropriate type of probe is extremely important. The probe tip diameter dictates the amount of sample that can be effectively processed. Smaller tip diameters (Microtip probes) deliver high intensity sonication but the energy is focused within a small, concentrated area. Larger tip diameters can process larger volumes, but offer lower intensity. Probes are offered with replaceable solid or sapphire tips.

Probe tips will pit or erode over time and require replacement. Using an excessively worn tip can affect your results and possibly overload the generator. Solid probes must be used when working with abrasive samples. Please review your different probe options and contact us for assistance with probe selection.
Type of Tip |
Processing Volume
|
Tip Diameter
|
Intensity
|
Amplitude
(microns) |
Cat. No. |
Replaceable Tip |
10-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-200 |
Solid Tip |
0-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-201 |
Sapphire Tip |
0-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-201S |
Replaceable Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-207 |
Solid Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-208 |
Sapphire Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-208S |
Replaceable Tip |
50-1,000 ml |
1" (25.4 mm) |
Low |
30 µm |
HS-209 |
Solid Tip |
50-1,000 ml |
1" (25.4 mm) |
Low |
30 µm |
HS-210 |
Replacement Tips for Standard Probes
 
Tip Diameter |
For Use With |
Cat. No. |
1/2" (12.7 mm) |
#200 |
HS-406 |
3/4" (19.1 mm) |
#207 |
HS-407 |
1" (25.4 mm) |
#210 |
HS-408 |
Microtip Probes

Microtips attach to the standard (HS-200) probe, except (HS-420) Stepped Microtip which attaches directly to the converter.
Processing Volume
|
Tip Diameter
|
Intensity
|
Amplitude
(microns) |
Cat. No.
|
0.2-5 ml |
1/16" (1.6 mm) |
Ultra High |
120 µm |
HS-418 |
0.5-15 ml |
1/8" (3.2 mm) |
Ultra High |
240 µm |
HS-419 |
2-25 ml |
3/16" (4.8 mm) |
Very High |
150 µm |
HS-419A |
5-50 ml |
1/4" (6.4 mm) |
High |
115 µm |
HS-419B |
0.5-15 ml |
1/8" (3.2 mm) |
Very High |
205 µm |
HS-420** |
**The (HS-420) Stepped Microtip has two sections: The upper section (HS-421) and lower (HS-422).
High Intensity Probes

High intensity probes are used instead of standard probes and offer double the amplitude of a standard probe.
Type of Tip
|
Processing Volume
|
Tip Diameter
|
Intensity
|
Amplitude
(microns) |
Cat. No.
|
Replaceable Tip |
25-500 ml |
3/4" (19.1 mm) |
High |
120 µm |
HS-305 |
Solid Tip |
25-500 ml |
3/4" (19.1 mm) |
High |
120 µm |
HS-306 |
Solid Tip |
50-1,000 ml |
1" (25.4 mm) |
Medium |
60 µm |
HS-310 |
Replaceable Tip |
50-1,000 ml |
1" (25.4 mm) |
Medium |
60 µm |
HS-311 |
Probe Extenders

Standard probes may not be long enough to fit down into long necked vessels. Extenders are available in 5" and 10" lengths. Extenders are attached to standard probes with replaceable tips of the same diameter.
Type of Tip
|
Processing Volume
|
Tip Diameter
|
Intensity
|
Amplitude
(microns) |
Cat. No.
|
Solid Tip |
10-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-406HW |
Replaceable Tip |
10-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-406HWT |
Sapphire Tip |
10-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-406HWS |
|
Solid Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-407HW |
Replaceable Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-407HWT |
Sapphire Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-407HWS |
|
Solid Tip |
50-1,000 ml |
1" (25.4 mm) |
Low |
30 µm |
HS-408HW |
Replaceable Tip |
50-1,000 ml |
1" (25.4 mm) |
Low |
30 µm |
HS-408HWT |
|
Solid Tip |
10-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-406FW |
Replaceable Tip |
10-250 ml |
1/2" (12.7 mm) |
High |
120 µm |
HS-406FWT |
|
Solid Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-407FW |
Replaceable Tip |
25-500 ml |
3/4" (19.1 mm) |
Medium |
60 µm |
HS-407FWT |
|
Solid Tip |
50-1,000 ml |
1" (25.4 mm) |
Low |
30 µm |
HS-408FW |
Replaceable Tip |
50-1,000 ml |
1" (25.4 mm) |
Low |
30 µm |
HS-408FWT |
Booster Probes

Boosters will increase the intensity of standard probes. Boosters attach between the converter and standard probe to increase amplitude by the gain ratio indicated below.
For Use With |
Gain Ratio |
Cat. No. |
3/4" and 1" probes |
2 to 1 |
HS-328A |
3/4" and 1" probes |
2.5 to 1 |
HS-328B |
*Amplitude measurement at setting 10 (100%)
Cup Horns

Cup horns offer indirect sonication and function as high intensity ultrasonic water baths. Samples can be processed in sealed tubes or vials eliminating aerosols and cross contamination. This method is ideal for sterile or pathogenic sample processing.
The titanium horn is held within an acrylic cup filled with water. Samples are placed within the cup, above the probe. Cavitation is produced in the water processing the samples within the tubes. Ports on either side of the cup allow you to circulate the water to reduce the heat created by sonication. A microtube holder is included with each Cup Horn.
Cat. No. |
HS-431A |
HS-431B |
HS-431C |
Inner Diameter of Cup |
2.5" (6.4cm) |
3" (7.6cm) |
5.5" (14.0cm) |
Diameter of Horn |
2" (5.1cm) |
2" (5.1cm) |
2.5" (6.4cm) |
Microtube Holder* |
HS-441 |
HS-442 |
HS-443 |
HS-431A and HS-431B are similar size and B models allow for more water to circulate around temperature sensitive samples. 431C enables you to use more samples or larger vessels.
Replacement Microtube Holders
| Replacement |
HS-441 |
HS-442 |
HS-443 |
Tube Capacity |
8 |
8 |
20 |
* Each unit comes with a microtube holder that fits the specified amount of 1.5ml tubes.
Microplate Horn

Microplate Horns process an entire microplate at one time. Similar to the Cup Horn, the Microplate Horn delivers indirect sonication. Simply place a microtiter plate within the water filled reservoir and the vibration is transferred into each individual well. This unit is ideal for high throughput applications.
If your work requires the use of microtubes or a vessel which is taller than a standard microplate, a Deep Well version of the Microplate Horn is also available. The Deep Well unit has a higher reservoir which holds a larger volume of water. More water is necessary to immerse deep well miroplates.
The Microplate Horn comes complete with a required sound enclosure to protect users from the sound generated by this horn. As well as all the fitments required to control and replace the water in the horn reservoir.
Dimensions |
Cat. No. |
Microplate Horn (6" wide x 3" deep) |
HS-431MPX |
HS-431MPX includes:
- Microplate Horn
- Acoustic Enclosure
- Pinch Clamps
- Silicone Tubing
Flowcells

Flocells are used for the continuous processing of large volumes of sample material. Flocells are ideal for mixing and dispersing applications and can accomodate flow rates up to 40 liters per minute. Three sizes are available and are constructed of stainless steel. A polycarbonate model is available which allows you to see the level of your sample. The annulus and orifice sizes are variable to accomodate differing viscosity and flow rates. Custom units can be made with sanitary fittings for sterile processes.
Cat. No. |
HS-800A |
HS-800B |
HS-800C |
HS-800D |
Maximum Flow Rating |
0.67 lpm |
0.67 lpm |
29 lpm |
40 lpm |
Static Pressure Rating |
50 psi (350 kPa) |
100 psi (700 kPa) |
100 psi (700 kPa) |
100 psi (700 kPa) |
Inlet/Outlet Size |
1/4" NPT |
1/4" NPT |
1/2" NPT |
1" NPT |
Material of Tube Body |
Polycarbonate |
Stainless Steel |
Stainless Steel |
Stainless Steel |
Please contactl Technical Support for assistance: technicalsupport@mandel.ca; 1-888-883-3636
Dual Horn

The Dual Horn allows a single sonicator and converter to process two samples simultaneously. The rectangular shaped horn doubles the unit's output, and enables 3/4" probes to vibrate with the same intensity as a single 3/4' probe.
The Dual Horn is capable of withstanding the rigors and harsh chemicals of environmental testing labs. Sonication is used by environmental labs to process soil and sediment samples in lieu of soxhlet extraction methods. The Sonicator and Dual Horn meet the EPA requirements specified in Method SW846-3550, which is referenced by the following analytical test methods (8040, 8060, 8080, 8090,8100,8120, 8140, 8250, 8270, 413.2, 418.1).
Dimensions |
Cat. No. |
Dual Horn |
HS-351 |
3/4" Solid Probe* |
HS-355 |
Converter Stand and Positioner |
HS-438 |
*The Dual Horn requires (2) HS-355 probes. The Converter Stand and Positioner is optional.
Sound Enclosure
| Dimensions |
Cat No. |
14.5" W x 23" H x 12" D |
HS-432B |
A Jack Stand (Cat. No. HS-357) is also available for use within the sound enclosure. The Jack Stand can raise and lower samples to a stationary probe mounted within the enclosure. |