H&E stain of a well-differentiated breast cancer fixed in HistoChoice® MB.	Same tissue as shown in above figure hybridized for estrogen receptor messenger RNA.

• Non-Formalin Based Tissue Fixative Designed for Molecular Biology Applications
• Preserves Antigenic Sites and Nucleic Acid Sites in Their Native State
• Tissues Retain Natural Look and Feel Compared to Formalin Fixed Tissues
• A Safe, Non-Toxic Fixative – Contains No Formaldehyde, Glutaraldehyde or Mercury

HistoChoice^® MB is specially formulated to preserve antigenic sites (for antibody probes) and nucleic acid sites (for in situ hybridizations) in their native state making predigestion or other recovery procedures for these important sites unnecessary. Primary antibodies can often be diluted several-fold due to the increased number of preserved antigenic sites, saving cost on every slide that you process. HistoChoice^® MB provides superior sensitivity. Markers can be observed at lower antibody levels. It makes an excellent transport medium and can be safely washed down the drain upon neutralization in most districts.

HistoChoice^® MB directly replaces common fixatives including: formaldehyde-based, alcoholbased,
Zenker’s, B5 & B3, Bouin’s and other fixatives, and provides superior results. Tissues fixed in HistoChoice^® MB exhibit vibrant staining, better nuclear and cytoplasmic detail and will retain a crisp appearance even after long-term fixation. HistoChoice^® MB fixed tissue also retains a much more natural look and feel than formalin fixed tissue. Softer tissues mean easier, smoother cutting and sectioning.

HistoChoice® Tissue Fixative is Protected Under US Patent #’s: 5,429,797, & 5,439,667 .
© 2005 AMRESCO, Inc. All rights reserved. HistoChoice® is a registered trademark of AMRESCO Inc.