Flow-through monitoring of radiolabelled compounds separated by chromatographic techniques has been established as one of the most powerful tools in many biochemistry related research areas. Radiolabelled compounds for drug, pesticide, metabolism and pharmacokinetic studies provide very high sensitivity and specificity which is not available with mass detection, UV, fluorescence or conductivity measurements. The FlowStar represents the latest enhancements in flow-through detectors for Radio HPLC.

FlowStar Features

• Random coincidence counting with chemiluminescence subtraction for best sensitivity
• Touch screen for easy operation and data representation
• Automatic cell detection and parameter presets
• Automatic HV shutdown for system safety
• Built in leak detector
• Integrated multi channel analyzer for improved service friendliness
• Onboard system performance tests with instrument based history function
• User access control with security lock
• Integrated A/D converter for external analog signals
• Dual analog output for easy connection to existing HPLC systems and can be interfaced with all HPLC systems currently on the market.
• Communication ports using USB or Ethernet
• Printout capabilities for chromatograms and parameters
• Two versions available – order with or without RadioStar software
• The stand-alone version with analog outputs compatible with UV type data stations
  (0-1 volts, with linear over range up to 3 volts).
• The fully PC driven version is under control of the powerful Windows software package RadioStar
• Further exclusive features are the control of the scintillation pump, fraction collector and waste valve to divert radioactive waste to a separate container.
• A wide range of flow cells are available, with automatic measuring cell recognition implemented in the FlowStar instrument.
• For admixture applications, where a liquid scintillator is continuously mixed with the column eluate,
  a mixing pump is required. The pump is separate from the main detector to eliminate the possibility of scintillator leaking into the detector and associated electronics. It is also possible to split the eluate stream prior to mixing.
• The liquid scintillator must be carefully selected to provide the optimum sensitivity for a given solvent system. For solid scintillator, the proven YG material, unique to Berthold Technologies, provides the ultimate in efficiency/background performance. The detector is equipped with the most sensitive 2”-photomultiplier tubes operating incoincidence. The coincidence time for each type of scintillator will vary, and by using automatic Optimized Coincidence Time (O.C.T) the best E2/B is achieved. Automatic optimization of the electronics to capture the complete energy spectrum of the isotope is also performed to ensure the monitoring of all detectable events.

Applications

• Metabolic research (urine, plasma, cell and plant-extracts)
• Pesticide research (residue studies)
• Labeling of antibodies and proteins
• Development, production and quality control of radio-chemicals

Cell Types

• Liquid Mixing
• Microbore
• HPLC/MS
• Gamma Isotopes and Positron Emitter PET (Teflon^® inner)
• Solid Scintillator
• Preparative SFC
• 125I (Teflon^® inner)
• 32P (Teflon^® inner)
• GLP Test Cells
• Custom-made cells