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The Nexera Prep SFC is a new preparative supercritical fluid chromatography system that builds on the successful analytical-scale Nexera UC with innovative, state-of-the-art preparative purification SFC technologies. It resolves a number of historical issues in SFC preparative purification, allowing users to overhaul their workflow, reduce labor and improve efficiency. Not only does the Nexera Prep SFC achieve superior fractionation recovery rates for preparative purification, it provides flexible system configurations in a compact design, minimizing bench footprint and allowing you to maximize lab resources.
Nexera can be set to start up at a specified time, so that it can complete auto-purge, equilibration and baseline checks in advance, and be ready for analysis as soon as you arrive at the lab. Moreover, the system can be set up in advance to run without user intervention all the way from start up through analysis to shutdown.
You can view the status and predicted analysis completion time for multiple systems from any location via a smart device. None of these features requires any special software.
In rare cases, air bubbles can form in the mobile phase and cause problems if inhaled into the pump. Nexera has the ability to monitor baseline changes and pressure fluctuations to check for abnormalities.
When it detects an unusual fluctuation, it can automatically pause the analysis, purge the flow path, and restart analysis once it has confirmed recovery to normal pressure.
HPLC columns can be damaged by sudden pump starts and stops or extreme gradient changes. The Nexera automatically uses FlowPilot (Smart Flow Control) to increase the flow rate gradually to the set point. There is no need to create startup protocols for each analysis.
Reservoir tray weight sensors (optional) can be used to monitor the volume of mobile phase or autosampler rinse solution in up to twelve containers. The containers can also be checked remotely from a smart device.
You will no longer need to worry about running out of mobile phase mid-analysis, because the device will notify you before starting the run if the volume remaining is too low.
The Nexera frees up bench space with a compact design two thirds the size of Shimadzu's previous model.
The Nexera uses over 70% less electricity when in standby mode, significantly reducing running costs and supporting an environmentally-friendly lab.
The touch panel screen and LabSolutions control screen display are uniform for easier operation.
Injection ports for two separate flow paths can be installed, allowing two different types of analysis (such as analysis of amino acids, organic acids or vitamins) to be performed using one system.
The Nexera boasts ultra-low carryover, even on a high-sensitivity LC/MS/MS. This reduces time spent on rinsing, resulting in a shorter overall analysis time.
The autosampler allows the insertion of additional vials and MTPs even during analysis. The sample rack structure controls air flow inside the autosampler to maintain the internal temperature and prevent condensation.
The SPD-M40 detector achieves an extremely high level of sensitivity and linearity (up to 2.5 AU). This allows quantitation of very lowconcentration impurities even in high-concentration samples. The UV cut-off filter installed in the detector prevents sample degradation due to UV light, helping to maintain good linearity at low concentrations.
Baseline fluctuations can affect peak area calculation, reducing the accuracy of quantitative results. The SPD-M40 photodiode array detector’s “Advanced TC-Optics” function adjusts the temperature of the flow cell, lamp, and optical system to lessen the impact of external temperature changes. Noise and drift have also been reduced by 40% compared to the previous model.
The SIL-40 autosampler can inject samples in as little as 5 seconds, twice as fast as the previous model. In addition, continuous analysis can be carried out on up to 44 MTPs (using 3 PLATE CHANGERS). Together these features dramatically increase analysis throughput. 8 injections can be completed within 1 minute (caffeine).
Pharmacokinetic analysis requires not only speed but also high reliability at low concentrations. With its ultra-fast injection and ultra-low carryover, the SIL-40 autosampler delivers high reproducibility and reliability, even during an ultra-fast 30-second analysis.
Non-stop temperature-controlled analysis of thousands of samples is now possible with the SIL-40's optional plate changers. Set all your samples in advance with up to 14 MTPs or vial racks in each PLATE CHANGER. The autosampler's excellent temperature control also allows the insertion of additional vials and MTPs during analysis.
The Nexera can automatically blend mobile phases at any set ratio. This speeds up the preparation of buffer solutions and the dilution of solvents, and can be used to easily prepare the exact amounts required for analysis, reducing waste as well as labour.
The Nexera Method Scouting System is capable of automatically switching between combinations of up to 6 columns and 8 mobile phases. It can run unattended, maximizing available uptime. In addition, Method Scouting Solution Software can automatically create methods with different columns, mobile phases, and gradient conditions from a single base method.