Nexera HPLC/UHPLC Column Ovens
Shimadzu has designed new 40 series column ovens to optimize thermal accuracy and stability. The new forced hot-air circulation with Peltier cooling designs are equipped with automatic fan speed control, maximizing thermal transfer between the heater and the column even in the case of power source voltage fluctuations.
Nexera HPLC/UHPLC Column Oven - CTO-40CShimadzu has designed the new 40 series column ovens to optimize temperature control accuracy and stability. The new forced hot air circulation with Peltier cooling designs are equipped with automatic fan speed control, maximizing thermal transfer between the heater and the column compartment even in the case of power source voltage fluctuations. The new CTO-40C is a full size, high capacity oven that holds various sizes of columns. A switching valve can be installed for multiple column use in method development. Precise and stable temperature control of the mobile phase, column, and sample improves retention time reproducibility for superior qualitative and quantitative analyses. The new built-in dual leak sensors detect tiny leakages of the mobile phase, leading to safer and more reliable performance. An optional active preheating system can even warm up the sample band and mobile phase before reaching the column. This optional unit preheats the column inlet tubing to match the set oven temperature to improve peak shape. CTO-40C Specifications
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Nexera HPLC/UHPLC Column Oven - CTO-40SShimadzu has designed the new 40 series column ovens to optimize temperature control accuracy and stability. The new forced hot air circulation with Peltier cooling designs are equipped with automatic fan speed control, maximizing thermal transfer between the heater and the column compartment even in the case of power source voltage fluctuations. The new CTO-40S Slim Line column oven is ideal for saving space while maintaining excellent thermal stability. The new built-in dual leak sensors can detect small leakages of the mobile phase. Warming up the sample band and mobile phase in the column inlet tubing to match the set oven temperature is possible with an optional preheating system. A switching valve can be installed for 2-column selction, and an additional valve can be added at the top of the oven for diverting flow to and away from an MS source.
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Fully Unattended Operation from Startup to Shutdown
Nexera can be set to start up at a specified time, so that it can complete auto-purge, equilibration and baseline checks in advance, and be ready for analysis as soon as you arrive at the lab. Moreover, the system can be set up in advance to run without user intervention all the way from start up through analysis to shutdown.
You can view the status and predicted analysis completion time for multiple systems from any location via a smart device. None of these features requires any special software.
Auto-Diagnostics and Recovery
In rare cases, air bubbles can form in the mobile phase and cause problems if inhaled into the pump. Nexera has the ability to monitor baseline changes and pressure fluctuations to check for abnormalities.
When it detects an unusual fluctuation, it can automatically pause the analysis, purge the flow path, and restart analysis once it has confirmed recovery to normal pressure.
FlowPilot Protects Columns
HPLC columns can be damaged by sudden pump starts and stops or extreme gradient changes. The Nexera automatically uses FlowPilot (Smart Flow Control) to increase the flow rate gradually to the set point. There is no need to create startup protocols for each analysis.
(Pat. Pending)
Mobile Phase Levels Measured in Real Time
Reservoir tray weight sensors (optional) can be used to monitor the volume of mobile phase or autosampler rinse solution in up to twelve containers. The containers can also be checked remotely from a smart device.
You will no longer need to worry about running out of mobile phase mid-analysis, because the device will notify you before starting the run if the volume remaining is too low.
(Pat. Pending)
Space-Saving Design
The Nexera frees up bench space with a compact design two thirds the size of Shimadzu's previous model.
Energy-Saving Standby Mode
The Nexera uses over 70% less electricity when in standby mode, significantly reducing running costs and supporting an environmentally-friendly lab.
Easy-to-use Touch Panel
The touch panel screen and LabSolutions control screen display are uniform for easier operation.
Dual Injection Enables Simultaneous Analysis
Injection ports for two separate flow paths can be installed, allowing two different types of analysis (such as analysis of amino acids, organic acids or vitamins) to be performed using one system.
Ultra-low Carryover
The Nexera boasts ultra-low carryover, even on a high-sensitivity LC/MS/MS. This reduces time spent on rinsing, resulting in a shorter overall analysis time.
Add Samples Mid-Analysis
The autosampler allows the insertion of additional vials and MTPs even during analysis. The sample rack structure controls air flow inside the autosampler to maintain the internal temperature and prevent condensation.
High-Sensitivity Impurity Analysis
The SPD-M40 detector achieves an extremely high level of sensitivity and linearity (up to 2.5 AU). This allows quantitation of very lowconcentration impurities even in high-concentration samples. The UV cut-off filter installed in the detector prevents sample degradation due to UV light, helping to maintain good linearity at low concentrations.
Stable Baseline
Baseline fluctuations can affect peak area calculation, reducing the accuracy of quantitative results. The SPD-M40 photodiode array detector’s “Advanced TC-Optics” function adjusts the temperature of the flow cell, lamp, and optical system to lessen the impact of external temperature changes. Noise and drift have also been reduced by 40% compared to the previous model.
(Pat. Pending)
Analysis Cycle Time Less Than 10 Seconds
The SIL-40 autosampler can inject samples in as little as 5 seconds, twice as fast as the previous model. In addition, continuous analysis can be carried out on up to 44 MTPs (using 3 PLATE CHANGERS). Together these features dramatically increase analysis throughput. 8 injections can be completed within 1 minute (caffeine).
Pharmacokinetic analysis requires not only speed but also high reliability at low concentrations. With its ultra-fast injection and ultra-low carryover, the SIL-40 autosampler delivers high reproducibility and reliability, even during an ultra-fast 30-second analysis.
Automated Analysis of Thousands of Samples
Non-stop temperature-controlled analysis of thousands of samples is now possible with the SIL-40's optional plate changers. Set all your samples in advance with up to 14 MTPs or vial racks in each PLATE CHANGER. The autosampler's excellent temperature control also allows the insertion of additional vials and MTPs during analysis.
Quick and Reliable Mobile Phase Blending
The Nexera can automatically blend mobile phases at any set ratio. This speeds up the preparation of buffer solutions and the dilution of solvents, and can be used to easily prepare the exact amounts required for analysis, reducing waste as well as labour.
Simplified Method Development
The Nexera Method Scouting System is capable of automatically switching between combinations of up to 6 columns and 8 mobile phases. It can run unattended, maximizing available uptime. In addition, Method Scouting Solution Software can automatically create methods with different columns, mobile phases, and gradient conditions from a single base method.
