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Hypoxic Chambers

When your research requires consistent atmospheric control to maintain hypoxia, normoxia, or hyperoxia, you can count on Coy’s Hypoxic Chambers. Easy to use and easy to customize, Coy’s complete line of glove boxes and cabinets allows you to maintain desired levels of O2, CO2, temperature, and humidity in either cell and tissue culture or animal applications.
 
How the system operates:
The feedback loop system uses an O2 sensor mounted inside the glove box/cabinet to monitor oxygen levels. Based on these sensor readings and the user-adjustable set points you establish, the system flushes the chamber with N2, displacing O2 and returning the chamber to ideal experimental conditions. For hyperoxic conditions an O2 source is added. It’s just that simple!
 
Not sure which Coy Hypoxic Chamber is right for you? In general, the best choice will depend on your answers to the following questions:
 
  •    How long will you need to incubate under your desired O2 level?
  •    Will you need to manipulate samples as part of your research?
  •    Do you need to maintain constant O2 levels or to cycle automatically between multiple levels?
Choose the cabinet that meets your laboratory's needs:
 

O2 Control In Vivo Glove Box

For Animal Studies

Maintain animals for extended periods of time under hypoxic or hyperoxic conditions, without ever exposing them to ambient air with Coy’s O2 Control Glove Box for Animal Studies. With oxygen and nitrogen gas sources connected to the O2 controller, the microprocessor controls gas purges based on sensor readings and the user-adjustable set point. Required animal care procedures can be performed while consistently maintaining uninterrupted hypoxia or hyperoxia.

 
All O2 Control Glove Boxes for Animal Studies include:
 
  • O2 control range from 0-100%
  • Factory calibrated for 0-20.9% O2 control (field calibration required)
  • Oxygen is controlled with user-adjustable set points in increments of 0.1% (option available for ramp and cycle)
  • Purge-only airlock (which, for optimum efficiency, can be custom-built based on the umber and size of the animals as well as their cage-size)
  • Glove box materials range from flexible vinyl to durable aluminum and polycarbonate
  • Interior power supply
  • Fan (heated or unheated)
Construction
Coy O2 Control Glove Boxes for Animal Studies are equipped with a purge-only airlock, which is a transfer chamber that equilibrates O2 levels by purging excess O2 or N2 prior to opening the door into the actual glove box and placing items inside. Automatic units use a specific preset time for purges based on protocol and desired glove box O2 levels. With manual units, the user operates a valve and times the purge.
Materials
 
Vinyl
  • Larger usable interior work space compared to most rigid glove boxes
  • Large gloves ports and flexible nature of the vinyl allow the user to reach deeper and higher into the glove box, providing greater ergonomic comfort when handling cumbersome cages
  • Removable rear equipment entry port (20”/508 mm diameter)
 
Rigid (Aluminum and Polymer)
  • Gloveless sleeves allow greater dexterity for the fine manipulations
  • Side door or optional removable front panel allows quick access to the glove box interior

O2 Control In Vitro Glove Box

For Tissue Culture

Perform incubation, culture maintenance & analysis in the same environment with Coy’s O2 Control Glove Box for Tissue Culture. O2 and CO2 concentrations will need to be adjusted from their normal atmospheric air concentrations within the experimental chamber or the glove box. N2 is used as a flush gas to displace the atmospheric gas mix to the experimental pre-sets. The controllers, combined with the sealed glove box and airlock, provide a more accurate and uninterrupted environment than an incubator or cabinet system by eliminating exposure to non-experimental conditions.

All O2 Control Glove Boxes for Tissue Culture are supplied with the following:
 
  • Control of O2 and CO2 in 0.1% increments
  • Gloveless sleeves (operator’s arms and hands may enter the box through the cuff-and-sleeve system without compromising the environment)
  • Large side door for initial equipment installation
  • Interior power supply
  • Arm port plugs seal box when operator is not working in it
  • Adjustable interior shelves
  • Gloves may be attached to sleeves
  • Patented diaphragm top to compensate for small volume changes (e.g. hands entering), increasing user ergonomic comfort
 
Construction
Coy O2 Control Glove Boxes are equipped with a purge-only airlock, which is a transfer chamber that equilibrates O2 levels by purging excess O2 prior to opening the door into the actual glove box and placing items inside. Automatic units use a specific preset time for purges based on on protocol and desired glove box O2 levels. Once preset, the airlock is operated with the touch of a button by lab personnel. With manual units, the user operates a valve and times the purge.
 
The Coy Humidified Incubation Box for Cell and Tissue Culture is a separate unit that sits inside the glove box. It allows cultures to be humidified with the same atmosphere content (gas and temperature) without immediately increasing the humidity of the rest of the box.
 
Materials
Coy O2 Control Glove Boxes for In Vitro Studies are available in polycarbonate (three standard sizes) and aluminum (two standard sizes). The choice of material depends on your research needs and budget. Aluminum is generally more robust and, therefore, has more service years than polycarbonate. Polycarbonate is a less expensive option and is easily customizable.

O2 Control In Vivo Cabinet

For Animal Studies

The Coy In Vivo Hypoxic Cabinet System is the only system of its type that is a hermetically sealed chamber and allows continuous control of oxygen. This hypoxic chamber allows animals to live at reduced or elevated O2 levels. The system features the ability to change the O2 levels between multiple set points in increments of 0.1%. Users need only to supply a gas source for nitrogen and oxygen. The System features an advance controller and sensor to precisely control your needs. Cabinet comes complete with fittings and pressure relief valve to make operation and set up easy.

 
Due to the wide variety of protocols on In Vivo hypoxia studies Coy offers a complete line of options to ensure your animal care needs are met.
 
All O2 Control In Vivo Cabinets are supplied with the following:
 
  • Pressure relief valve
  • Two sensor ports
  • Circulation fan
  • Gas Inlet
  • Optional pullout shelf for Model 30 unit
  • O2 control range from 1-100%; factory calibrated for 0-20.9% (field calibration required)
  • Adjustable leveling pads
 
Construction
With oxygen and nitrogen gas sources connected to the O2 controller, the microprocessor controls gas purges based on sensor readings and the user-adjustable setpoint. Unlike other systems, there is no continuous purge of gas into the cabinet. This hypoxic chamber’s hermetic seal ensures that even with the controller detached, you can maintain preset O2 levels for periods of time depending on experimental conditions. This translates into less gas consumption compared to a semi sealed cabinet.

O2 Control In Vitro Cabinet

For Cell Cultures

The Coy In Vitro Hypoxic Cabinet System is the only system of its type that is a hermetically sealed chamber and allows continuous control of oxygen. The system features result in less gas consumption (lower operating cost) and more reproducible oxygen results when compared to tri-gas incubators and other cabinet systems. In Vitro cabinets are designed to use existing lab incubators for temperature control while completely controlling oxygen levels (and optionally, CO2) inside the cabinet.

 
All O2 Control In Vitro Cabinets are supplied with the following:
 
  • O2 controller and sensor
  • Pressure relief valve
  • Two sensor ports
  • Circulation fan
  • Gas inlet
  • Pullout sliding shelves
  • Humidification trays
  • Adjustable leveling pads
 
Construction
Pullout shelves, spaced 1.5″ apart, provide easy access to samples. Humidity is achieved from water in a high-surface-area tray. The system also offers the ability to change the O2 levels between multiple setpoints in increments of 0.1%.
 
The microprocessor controls gas purges based on the sensor reading and user-adjustable setpoint. This system does not require continuous purge of gas into the cabinet. Depending on the application, you will need to supply one or all of the following gases: nitrogen, nitrogen with CO2 mix, and O2.
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